Sarcoidosis is an inflammatory disease characterized by the formation of granulomas—clusters of immune cells—in organs such as the lungs, lymph nodes, skin, and eyes. While its exact cause remains unknown, it’s thought to stem from an overactive immune response. Traditional treatments often involve corticosteroids or immunosuppressive medications, which can bring significant side effects with long-term use. In recent years, research into cannabis and the endocannabinoid system has opened new avenues for managing inflammatory conditions like sarcoidosis. Cannabinoids such as CBD (cannabidiol) and THC (tetrahydrocannabinol) interact with CB1 and CB2 receptors found throughout the immune system, where they can modulate immune activity, reduce cytokine production, and help regulate inflammatory pathways.
Preclinical evidence and patient reports suggest that cannabinoids may help alleviate symptoms associated with sarcoidosis, including chronic pain, fatigue, and shortness of breath. CBD, in particular, has demonstrated strong anti-inflammatory and antifibrotic properties, which could help limit tissue damage and promote healing in affected organs. While more clinical studies are needed to confirm these effects specifically in sarcoidosis, existing research supports cannabis as a potential adjunct therapy—offering a more natural, well-tolerated option for symptom relief and immune balance. For many patients, incorporating cannabinoids into a holistic treatment plan may help reduce reliance on steroids, improve overall quality of life, and bring the immune system back into better alignment.